Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy.

@article{Choi2011SmartNB,
  title={Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy.},
  author={Ki Young Choi and Hong Yeol Yoon and Jong-Ho Kim and Sang Mun Bae and R K Park and Young Mo Kang and In-San Kim and Ick Chan Kwon and Kuiwon Choi and Seo Jeong and Kwangmeyung Kim and Jae Hyung Park},
  journal={ACS nano},
  year={2011},
  volume={5 11},
  pages={8591-9}
}
Tumor targetability and site-specific drug release of therapeutic nanoparticles are key factors for effective cancer therapy. In this study, poly(ethylene glycol) (PEG)-conjugated hyaluronic acid nanoparticles (P-HA-NPs) were investigated as carriers for anticancer drugs including doxorubicin and camptothecin (CPT). P-HA-NPs were internalized into cancer cells (SCC7 and MDA-MB-231) via receptor-mediated endocytosis, but were rarely taken up by normal fibroblasts (NIH-3T3). During in vitro drug… CONTINUE READING
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