Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy.

  title={Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy.},
  author={Ki Young Choi and Hong Yeol Yoon and Jong-Ho Kim and Sang Mun Bae and R K Park and Young Mo Kang and In-San Kim and Ick Chan Kwon and Kuiwon Choi and Seo Jeong and Kwangmeyung Kim and Jae Hyung Park},
  journal={ACS nano},
  volume={5 11},
Tumor targetability and site-specific drug release of therapeutic nanoparticles are key factors for effective cancer therapy. In this study, poly(ethylene glycol) (PEG)-conjugated hyaluronic acid nanoparticles (P-HA-NPs) were investigated as carriers for anticancer drugs including doxorubicin and camptothecin (CPT). P-HA-NPs were internalized into cancer cells (SCC7 and MDA-MB-231) via receptor-mediated endocytosis, but were rarely taken up by normal fibroblasts (NIH-3T3). During in vitro drug… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 81 extracted citations


Publications referenced by this paper.
Showing 1-10 of 40 references

Self-Assembled Hyaluronic Acid Nanoparticles as a Potential Drug Carrier for Cancer Therapy: Synthesis, Characterization, and in Vivo Biodistribution

  • K. Y. Choi, K. H. Min, +5 authors S. Y. Jeong
  • J. Mater. Chem. 2009,
  • 2009

Antitumor Efficacy of Cisplatin-Loaded Glycol Chitosan Nanoparticles in Tumor-Bearing Mice

  • J. H. Kim, Y. S. Kim, +7 authors S. Y Jeong
  • J. Controlled Release
  • 2008

Similar Papers

Loading similar papers…