Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles.

@article{Baek2015SmartMD,
  title={Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles.},
  author={Seonmi Baek and Rajendra Kumar Singh and Dipesh Khanal and Kapil D. Patel and Eun-Jung Lee and Kam W. Leong and Wojciech Chrzanowski and Hae Won Kim},
  journal={Nanoscale},
  year={2015},
  volume={7 34},
  pages={
          14191-216
        }
}
Nanomedicine seeks to apply nanoscale materials for the therapy and diagnosis of diseased and damaged tissues. Recent advances in nanotechnology have made a major contribution to the development of multifunctional nanomaterials, which represents a paradigm shift from single purpose to multipurpose materials. Multifunctional nanomaterials have been proposed to enable simultaneous target imaging and on-demand delivery of therapeutic agents only to the specific site. Most advanced systems are also… 

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References

SHOWING 1-10 OF 180 REFERENCES

Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles--opportunities & challenges.

TLDR
Some safety issues regarding MSNs are discussed and how different features of the drug delivery platform influence their behaviour in a biological setting are highlighted, which will facilitate the application of MSNs in nanomedicine.

Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor‐targeted drug delivery vectors

TLDR
This work discusses the development of colloidal gold‐based drugs that are designed to target the delivery of TNF and paclitaxel to solid tumors and attempts to build such multifunctional nanotherapeutics using colloidalgold nanoparticles.

Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs.

TLDR
The preparation of fluorescent mesoporous silica nanoparticles that are highly stable in aqueous solution and their use for the delivery of the hydrophobic anticancer drug CPT are described.

Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery.

TLDR
The different surface modifications made to MSNs that have allowed for the construction of targeted nanoparticles to enhance accumulation and uptake in target sites are discussed, the incorporation of nanomachines for controlled cargo release and the combination with superparamagnetic metals for MRI cell labeling are discussed.

Mechanized silica nanoparticles: a new frontier in theranostic nanomedicine.

TLDR
The evolution of various MSNPs is chronicle, advances in the synthesis of novel hybrid SNPs and the various MIMs which have been attached to their surfaces are discussed, and the design of more robust theranostic delivery systems are focused on using mesoporous silica nanoparticles (SNPs).

Mesoporous silica nanoparticles for intracellular controlled drug delivery.

TLDR
The latest research on the pathways of entry into live mammalian and plant cells together with intracellular trafficking are described, and the current research progress on the biocompatibility of this material in vitro and in vivo is discussed.

Functionalized mesoporous silica materials for controlled drug delivery.

TLDR
This review highlights the most recent research progress on silica-based controlled drug delivery systems, including pure mesoporous silica sustained-release systems, magnetism and/or luminescence functionalized mesoporus silica systems which integrate targeting and tracking abilities of drug molecules.

Functionalized Mesoporous Silica Materials for Controlled Drug Delivery

TLDR
This review highlights the most recent research progress on silica-based controlled drug delivery systems, including pure mesoporous silica sustained-release systems, magnetism and/or luminescence functionalized mesoporus silica systems which integrate targeting and tracking abilities of drug molecules.

Nanogels as potential nanomedicine carrier for treatment of cancer: A mini review of the state of the art

  • Govind SoniK. Yadav
  • Biology, Engineering
    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  • 2016
...