Smart drug delivery systems: from fundamentals to the clinic.

@article{AlvarezLorenzo2014SmartDD,
  title={Smart drug delivery systems: from fundamentals to the clinic.},
  author={Carmen Alvarez‐Lorenzo and Angel Concheiro},
  journal={Chemical communications},
  year={2014},
  volume={50 58},
  pages={
          7743-65
        }
}
Forty years after the first reports on stimuli-responsive phase transitions in synthetic hydrogels, the first medicines based on responsive components are approaching the market. Sensitiveness to internal or external signals of the body can be achieved by means of materials (mostly polymers, but also lipids and metals) that modify their properties as a function of the intensity of the signal and that enable the transduction into changes in the delivery system that affect its ability to host… 
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