Smart and cationic poly(NIPA)/PEI block copolymers as non-viral vectors: in vitro and in vivo transfection studies.

Abstract

In this study, in vitro and in vivo transfection of temperature-sensitive, polycationic poly(N-isopropylacrylamide) and polyethyleneimine copolymers (poly(NIPA)/PEI25L) were performed. Copolymer and copolymer-plasmid DNA (pDNA) complexes were positively charged as + 7.6 and + 12.8, respectively. Gel retardation assay confirmed good complex formation and… (More)

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