Smallpox vaccines for biodefense: need and feasibility

@article{Artenstein2008SmallpoxVF,
  title={Smallpox vaccines for biodefense: need and feasibility},
  author={Andrew W. Artenstein and John D. Grabenstein},
  journal={Expert Review of Vaccines},
  year={2008},
  volume={7},
  pages={1225 - 1237}
}
Smallpox, eradicated as a cause of natural disease through an intensive global effort in the later part of the 20th Century, has resurfaced as a possible agent of bioterrorism. For this reason, there is renewed interest in smallpox vaccines. Live vaccinia virus, an orthopoxvirus related to smallpox, has a long and successful clinical track record as an effective smallpox vaccine; however, its use is associated with uncommon yet serious adverse events. This has led to a surge of recent research… 
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37 Citations
Highly Influential Citations
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Background Citations
20
Methods Citations
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37 Citations

Smallpox vaccines: New formulations and revised strategies for vaccination
TLDR
The history of smallpox vaccines and recent achievements in the development of highly efficacious and safer vaccines and vaccine applications are reviewed and assessment of adequate animal models to study pathogenesis and protective immunity is reviewed.
Smallpox vaccines for biodefense.
The immunology of smallpox vaccines.
Development of an attenuated smallpox vaccine candidate: The KVAC103 strain.
Smallpox and bioterrorism
TLDR
A public-health response to smallpox as using for bioterrorism is described, with great concern that smallpox is an excellent candidate for use as a terrorist weapon.
Safe and Effective Smallpox Vaccine Development Using DNA Vaccines and In vivo Electroporation
TLDR
This review summarizes recent data supporting vaccine development using DNA and electroporation to protect the general public in the event of a bioterror incident using smallpox.
Co-administration of tecovirimat and ACAM2000â„¢ in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge.
Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice.
Safety and immunogenicity of LC16m8, an attenuated smallpox vaccine in vaccinia-naive adults.
TLDR
LC16m8 generates neutralizing antibody titers to multiple poxviruses, including vaccinia, monkeypox, and variola major, and broad T-cell responses, indicating that LC 16m8 may have efficacy in protecting individuals from smallpox.
T Lymphocytes as Measurable Targets of Protection and Vaccination Against Viral Disorders
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