Smallpox vaccines for biodefense: need and feasibility

@article{Artenstein2008SmallpoxVF,
  title={Smallpox vaccines for biodefense: need and feasibility},
  author={A. Artenstein and J. Grabenstein},
  journal={Expert Review of Vaccines},
  year={2008},
  volume={7},
  pages={1225 - 1237}
}
  • A. Artenstein, J. Grabenstein
  • Published 2008
  • Medicine
  • Expert Review of Vaccines
    • Smallpox, eradicated as a cause of natural disease through an intensive global effort in the later part of the 20th Century, has resurfaced as a possible agent of bioterrorism. For this reason, there is renewed interest in smallpox vaccines. Live vaccinia virus, an orthopoxvirus related to smallpox, has a long and successful clinical track record as an effective smallpox vaccine; however, its use is associated with uncommon yet serious adverse events. This has led to a surge of recent research… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 131 REFERENCES
    Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox
    • 295
    Modified vaccinia Ankara: potential as an alternative smallpox vaccine.
    • 82
    • PDF
    LC16m8: An attenuated smallpox vaccine
    • 74
    Smallpox vaccines: Past, present, and future.
    • 85
    Smallpox DNA Vaccine Protects Nonhuman Primates against Lethal Monkeypox
    • 213
    • PDF
    Edward Jenner and the History of Smallpox and Vaccination
    • 412
    • PDF
    New generation smallpox vaccines: a review of preclinical and clinical data
    • 51
    Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine.
    • 122
    An update on smallpox vaccine candidates and their role in bioterrorism related vaccination strategies.
    • 36
    Clonal vaccinia virus grown in cell culture as a new smallpox vaccine
    • 133