Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity.

@article{Liszewski2009SmallpoxIO,
  title={Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity.},
  author={M. Kathryn Liszewski and Marilyn K. Leung and Richard E. Hauhart and Celia J. Fang and Paula Bertram and John P Atkinson},
  journal={Journal of immunology},
  year={2009},
  volume={183 5},
  pages={3150-9}
}
Although smallpox was eradicated as a global illness more than 30 years ago, variola virus and other related pathogenic poxviruses, such as monkeypox, remain potential bioterrorist weapons or could re-emerge as natural infections. Poxviruses express virulence factors that down-modulate the host's immune system. We previously compared functional profiles of the poxviral complement inhibitors of smallpox, vaccinia, and monkeypox known as SPICE, VCP (or VICE), and MOPICE, respectively. SPICE was… CONTINUE READING