Therapeutic Vaccines and Antibodies for Treatment of Orthopoxvirus Infections
- Medicine, BiologyViruses
This paper summarizes some of the historic use of the smallpox vaccine and immunoglobulins in the post-exposure setting in humans and reviews in detail the newer animal studies that address the use of therapeutic vaccines and immune globulin in orthopoxvirus infections as well as the development of new therapeutic monoclonal antibodies.
Laboratory diagnosis of smallpox: role of the Virus Reference Laboratory, Colindale, 1947–70
- MedicineJournal of Hygiene
The Virus Reference Laboratory, Colindale, first embarked on laboratory investigations for smallpox early in 1947 and provided a complete diagnostic service throughout England and Wales until 1962, after which the service became available regionally until eradication was effected.
Laboratory differential diagnosis of vesicular skin rashes.
Antivaccinial gamma-globulin; a further report on smallpox prophylaxis.
Anti-vaccinial gamma-globulin in smallpox prophylaxis.
Hyperimmune vaccinal gamma globulin; source, evaluation, and use in prophylaxis and therapy.
It would appear that the experience so far is encouraging enough to continue and to expand the use of hyperimmune vaccinal gamma globulin in the prophylaxis and therapy of serious dermal complications of smallpox vaccination.