Smallpox: a review of clinical disease and vaccination.

  title={Smallpox: a review of clinical disease and vaccination.},
  author={Jennifer M Lofquist and Nicole A. Weimert and Mary S Hayney},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  volume={60 8},
          749-56; quiz 757-8
The clinical course of smallpox infection and the current and future roles of vaccination and strategies for controlling smallpox outbreaks are reviewed. Close personal contact is required for transmission of variola, the DNA virus that causes smallpox. Following an incubation period, infected persons have prodromal symptoms that include high fever, back pain, malaise, and prostration. The eruptive stage is characterized by maculopapular rash that progresses to papules, then vesicles, and then… CONTINUE READING

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