Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy

@article{Inagaki2007SmallerRV,
  title={Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy},
  author={Masatoshi Inagaki and Eisho Yoshikawa and Yutaka J. Matsuoka and Yuriko Sugawara and Tomohito Nakano and Tatsuo Akechi and Noriaki Wada and Shigeru Imoto and Koji Murakami and Yosuke Uchitomi},
  journal={Cancer},
  year={2007},
  volume={109}
}
Previous studies have shown cognitive impairment in breast cancer survivors who were exposed to adjuvant chemotherapy. Neural damage by chemotherapy might have played some part in these findings. The current study explored the regional brain volume difference between breast cancer survivors exposed to adjuvant chemotherapy (C+) and those unexposed (C−). 
Global and focal white matter integrity in breast cancer survivors 20 years after adjuvant chemotherapy
TLDR
This work investigated the long‐term effect of chemotherapy on white matter microstructural integrity by comparing the brains of chemotherapy‐exposed breast cancer survivors to those of a population‐based sample of women without a history of cancer.
Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy
TLDR
Adjuvant chemotherapy for breast cancer is associated with long-term reductions in TBV and overall gray matter volume in the absence of focal reductions, and volume differences might be associated with the slightly worse cognitive performance in this group of breast cancer survivors.
Chemotherapy-induced brain changes in breast cancer survivors: evaluation with multimodality magnetic resonance imaging
TLDR
The potential applications of multimodality MR imaging techniques in chemotherapy induced cognitive deficit in breast cancer survivors and future research perspective in this field are outlined.
Association between structural measures of specific regional brain volumes measured by quantitative magnetic resonance imaging and neurocognitive performance in elderly breast cancer survivors exposed to chemotherapy
TLDR
Association between structural measures of specific regional brain volumes measured by quantitative magnetic resonance imaging and neurocognitive performance in elderly breast cancer survivors exposed to chemotherapy is studied.
Smaller regional volumes of gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy
TLDR
In the light of the increasing survival of patients with primary, high-risk breast cancer because of adjuvant chemotherapy, the control of therapy-associated, potentially long-term, persisting, adverse effects is essential.
Alterations in brain structure related to breast cancer and its treatment: chemotherapy and other considerations
TLDR
A review of currently available published observations of cognitive effects of cancer and its treatment discusses the major themes and promising directions for future studies.
Integrating imaging findings in evaluating the post-chemotherapy brain
TLDR
This review examines recent neuroimaging studies on cancer- and chemotherapy-related cognitive dysfunction in non-central nervous system cancers and compares findings across imaging modalities to assist in characterizing the dysfunction reported by patients and contribute to a better understanding of the mechanisms involved.
Late effects of high‐dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: Converging results from multimodal magnetic resonance imaging
TLDR
It is suggested that high‐dose adjuvant chemotherapy for breast cancer is associated with long‐term injury to white matter, presumably reflecting a combination of axonal degeneration and demyelination, and damage to gray matter with associated functional deficits.
Association between adjuvant regional radiotherapy and cognitive function in breast cancer patients treated with conservation therapy
TLDR
It was showed that breast cancer patients exposed to adjuvant regional radiotherapy in conservation therapy might have cognitive impairment even several months after their treatment, partially mediated by elevation of plasma IL‐6 levels.
Assessing brain volume changes in older women with breast cancer receiving adjuvant chemotherapy: a brain magnetic resonance imaging pilot study
TLDR
The results suggest that different chemotherapy regimens may have differential effects on brain volume and cognition in older women with breast cancer receiving adjuvant chemotherapy.
...
...

References

SHOWING 1-10 OF 44 REFERENCES
No adverse effects of adjuvant chemotherapy on hippocampal volumein Japanese breast cancer survivors
TLDR
There were no significant differences in hippocampal volume or memory function or additionally in memory function between the two groups of Japanese breast cancer survivors with and without adjuvant chemotherapy.
The cognitive sequelae of standard‐dose adjuvant chemotherapy in women with breast carcinoma
TLDR
A prospective, longitudinal trial that incorporates baseline neuropsychologic evaluations is necessary to determine to what extent cognitive dysfunction is attributable to chemotherapy in this population of patients with breast carcinoma.
Late effects of adjuvant chemotherapy on cognitive function: a follow-up study in breast cancer patients.
TLDR
The results suggest that cognitive dysfunction following adjuvant chemotherapy in breast cancer patients may be transient, and additional studies are needed to investigate the differential attrition of patients with cognitive impairment.
Mild cognitive impairment after adjuvant chemotherapy in breast cancer patients - evaluation of appropriate research design and methodology to measure symptoms
TLDR
It is found that chemotherapy-induced MCI appears to occur in 10-40% of patients, and memory loss and lack of concentration are the most frequent symptoms, and research needs to be randomized and longitudinal with a base measurement point before the chemotherapy cycle starts.
The impact of adjuvant therapy for breast cancer on cognitive function: current evidence and directions for research.
TLDR
Although the neurocognitive changes appear to be subtle, there may be enough data to consider discussing the possibility of cognitive dysfunction as an adverse effect when assessing the risks and benefits of adjuvant chemotherapy.
Adjuvant breast cancer treatment and cognitive function: current knowledge and research directions.
TLDR
If an effect of systemic adjuvant therapy on cognitive function is confirmed, such an effect will have implications for informed consent and in the investigation of preventive interventions that might minimize the impact of cognitive dysfunction after cancer treatment.
Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma.
  • T. Ahles, A. Saykin, P. Silberfarb
  • Medicine, Psychology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2002
TLDR
Data from this study support the hypothesis that systemic chemotherapy can have a negative impact on cognitive functioning as measured by standardized neuropsychologic tests and self-report of memory changes and suggest that only a subgroup of survivors may experience long-term cognitive deficits associated with systemic chemotherapy.
A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function
TLDR
The purposes of this metaanalysis were to estimate the effect sizes for the effect of chemotherapy on each domain of cognitive function and to differentiate effect sizes by each method of comparison of effects.
Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives.
TLDR
Large-scale prospective studies are needed to help isolate the pathophysiological mechanisms underlying the cognitive deficits associated with chemotherapy, and studies of other brain disorders or treatment effects that might serve as a model for imaging chemotherapy-induced changes are noted.
...
...