Smaller orbital frontal cortex volumes associated with functional disability in depressed elders.

@article{Taylor2003SmallerOF,
  title={Smaller orbital frontal cortex volumes associated with functional disability in depressed elders.},
  author={Warren D. Taylor and David C. Steffens and Douglas R. McQuoid and Martha E. Payne and Shwu-Hua Lee and Te-jen Lai and K. Ranga R. Krishnan},
  journal={Biological psychiatry},
  year={2003},
  volume={53 2},
  pages={144-9}
}
BACKGROUND Depression is associated with significant functional impairment. Recent evidence has linked the orbital frontal cortex (OFC) with depression. We examined the relationship between OFC volumes in older subjects and impairment in the basic (BADL) and instrumental (IADL) activities of daily living. METHODS The sample consisted of 81 subjects aged 60 years or older; 41 were depressed subjects and 40 healthy control subjects. In a structured interview, subjects reported their medical… CONTINUE READING
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