Smaller left anterior cingulate cortex volumes are associated with impaired hypothalamic-pituitary-adrenal axis regulation in healthy elderly men.

@article{MacLullich2006SmallerLA,
  title={Smaller left anterior cingulate cortex volumes are associated with impaired hypothalamic-pituitary-adrenal axis regulation in healthy elderly men.},
  author={Alasdair M. J. MacLullich and Karen J. Ferguson and Joanna M. Wardlaw and John M. Starr and Ian J. Deary and Jonathan R Seckl},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 4},
  pages={1591-4}
}
CONTEXT Studies in animals suggest that the limbic prefrontal cortex, including the anterior cingulate cortex, is involved in regulation of the hypothalamic-pituitary-adrenal (HPA) axis, but human data are lacking. OBJECTIVE This study tested the hypothesis that smaller anterior cingulate cortex volumes are associated with HPA axis dysregulation in healthy older men. DESIGN AND PARTICIPANTS Comparison was made of volumes of bilateral anterior cingulate cortex, hippocampus, and superior… CONTINUE READING

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