Smaller amygdala volume and reduced anterior cingulate gray matter density associated with history of post-traumatic stress disorder.

@article{Rogers2009SmallerAV,
  title={Smaller amygdala volume and reduced anterior cingulate gray matter density associated with history of post-traumatic stress disorder.},
  author={Mark A. Rogers and Hidenori Yamasue and Osamu Abe and Haruyasu Yamada and Toshiyuki Ohtani and Akira Iwanami and Shigeki Aoki and Nobumasa Kato and Kiyoto Kasai},
  journal={Psychiatry research},
  year={2009},
  volume={174 3},
  pages={210-6}
}
Although post-traumatic stress disorder (PTSD) may be seen to represent a failure to extinguish learned fear, significant aspects of the pathophysiology relevant to this hypothesis remain unknown. Both the amygdala and hippocampus are necessary for fear extinction occur, and thus both regions may be abnormal in PTSD. Twenty-five people who experienced the Tokyo subway sarin attack in 1995, nine who later developed PTSD and 16 who did not, underwent magnetic resonance imaging (MRI) with manual… CONTINUE READING
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