• Corpus ID: 215814156

Smaller $p$-values in genomics studies using distilled historical information

@article{Bryan2020SmallerI,
  title={Smaller \$p\$-values in genomics studies using distilled historical information},
  author={Jordan G Bryan and Peter D. Hoff},
  journal={arXiv: Applications},
  year={2020}
}
Medical research institutions have generated massive amounts of biological data by genetically profiling hundreds of cancer cell lines. In parallel, academic biology labs have conducted genetic screens on small numbers of cancer cell lines under custom experimental conditions. In order to share information between these two approaches to scientific discovery, this article proposes a "frequentist assisted by Bayes" (FAB) procedure for hypothesis testing that allows historical information from… 

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On the use of historical estimates
TLDR
A mathematical formulation and a principled methodology are provided for addressing the problem of drawing inferences in the presence of historical data, and three distinct variants are investigated in detail.

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