Small-world network topology of hippocampal neuronal network is lost, in an in vitro glutamate injury model of epilepsy.

Abstract

Neuronal network topologies and connectivity patterns were explored in control and glutamate-injured hippocampal neuronal networks, cultured on planar multielectrode arrays. Spontaneous activity was characterized by brief episodes of synchronous firing at many sites in the array (network bursts). During such assembly activity, maximum numbers of neurons are… (More)

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