Small vulvar squamous cell carcinomas and adjacent tissues. A morphologic study

@article{Poulsen2003SmallVS,
  title={Small vulvar squamous cell carcinomas and adjacent tissues. A morphologic study},
  author={Hemming Poulsen and Jette Junge and Mogens Vyberg and Thomas Horn and Finn Lundvall},
  journal={APMIS},
  year={2003},
  volume={111}
}
Vulvar squamous cell carcinomas are of different subtypes and degrees of differentiation, and may be associated with adjacent lichen sclerosus and/or varying degrees of dysplasia. The aim of this investigation was to study small carcinomas with a diameter of less than 2 cm in order to find a possible relation between subtypes of carcinomas and adjacent epithelial changes. 
Progression of simplex (differentiated) vulvar intraepithelial neoplasia to invasive squamous cell carcinoma: a prospective case study confirming its precursor role in the pathogenesis of vulvar cancer.
  • A. Roma, W. R. Hart
  • Biology, Medicine
  • International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
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TLDR
This study conclusively demonstrates that simplex VIN is a distinct type of squamous intraepithelial carcinoma (ie, carcinoma in situ) and a direct precursor of keratinizing SCC. Expand
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TLDR
The theory that simplex VIN is the most likely precursor of conventional keratinizing SCC, the most common type of vulvar invasive carcinoma, is supported. Expand
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The relationship between lichen sclerosus and squamous cell and verrucous carcinomas, the possible oncogenic mechanisms involved, and their possible association with HPV infection are considered. Expand
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TLDR
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TLDR
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Differentiated-Type Vulval Intraepithelial Neoplasia Has a High-Risk Association With Vulval Squamous Cell Carcinoma
TLDR
Differentiated-type VIN is significantly more associated with vulval squamous cell carcinoma than usual- type VIN, and the numbers of women with prior, synchronous, or subsequent vulval Squamous Cell carcinoma were 44 (25.7%) and 53 (31.7%), respectively. Expand
Differentiated-Type Vulval Intraepithelial Neoplasia Has a High-Risk Association With Vulval Squamous Cell Carcinoma
TLDR
Differentiated-type VIN is significantly more associated with vulval squamous cell carcinoma than usual- type VIN, and the numbers of women with prior, synchronous, or subsequent vulval Squamous Cell carcinoma were 44 (25.7%) and 53 (31.7%), respectively. Expand
In the absence of (early) invasive carcinoma, vulvar intraepithelial neoplasia associated with lichen sclerosus is mainly of undifferentiated type: new insights in histology and aetiology
TLDR
VIN related to LS without coexisting SCC is likely to be undifferentiated, in contrast to what was previously thought. Expand
Smoking and multicentric vulval intraepithelial neoplasia
TLDR
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Do Langerhans cells play a role in vulvar epithelium resistance to squamous cell carcinoma?
TLDR
It is postulated that the reduction in the number of LCs may be one of the reasons for a higher tendency of carcinogenesis in the vulvar region. Expand
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The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women
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