Small-volume resuscitation with hypertonic saline (2,400 mOsm/liter) during hemorrhagic shock.

@article{Nakayama1984SmallvolumeRW,
  title={Small-volume resuscitation with hypertonic saline (2,400 mOsm/liter) during hemorrhagic shock.},
  author={Seiya Nakayama and Ludwell Sibley and Robert A. Gunther and James W. Holcroft and George C. Kramer},
  journal={Circulatory shock},
  year={1984},
  volume={13 2},
  pages={149-59}
}
We compared small-volume resuscitation using either normal saline or hypertonic saline (2400 mOsm/liter) during hemorrhagic hypotension. Six unanesthetized sheep were bled to 50 mm Hg mean arterial pressure and maintained for 2 h. During this shock period cardiac output decreased 40-50% of baseline, while total peripheral resistance increased 20-30%. Then the response to a bolus injection of either hypertonic saline or normal saline, randomly chosen, was studied for an additional 2 h. The… CONTINUE READING
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