Small targeted cytotoxics from DNA-encoded chemical libraries.

  title={Small targeted cytotoxics from DNA-encoded chemical libraries.},
  author={Florent Samain and Giulio Casi},
  journal={Current opinion in chemical biology},
Conventional chemotherapeutic drugs do not selectively localize to tumors, causing undesired toxicities to healthy organs, and precluding the escalation to therapeutically active regimens. The selective delivery at sites of disease of potent effector molecules represents a promising strategy for the treatment of cancer and other diseases. High affinity antibodies towards disease-associated antigens are currently the vehicles of choice for the targeted delivery of payloads. Low molecular weight… CONTINUE READING