Small size ionic heterogeneities in the human heart can attract rotors.

@article{Defauw2014SmallSI,
  title={Small size ionic heterogeneities in the human heart can attract rotors.},
  author={Arne Defauw and Nele Vandersickel and Peter Dawyndt and Alexander V. Panfilov},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2014},
  volume={307 10},
  pages={
          H1456-68
        }
}
Rotors occurring in the heart underlie the mechanisms of cardiac arrhythmias. Answering the question whether or not the location of rotors is related to local properties of cardiac tissue has important practical applications. This is because ablation of rotors has been shown to be an effective way to fight cardiac arrhythmias. In this study, we investigate, in silico, the dynamics of rotors in two-dimensional and in an anatomical model of human ventricles using a Ten Tusscher-Noble-Noble… 
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Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern
TLDR
In the presence of a scar, rotors were eventually dynamically anchored from large distances by the fibrotic scar via a process of dynamical reorganization of the excitation pattern, which coalesces with a change from polymorphic to monomorphic ventricular tachycardia.
Anisotropic shortening in the wavelength of electrical waves promotes onset of electrical turbulence in cardiac tissue: An in silico study
TLDR
A possible mechanism for the development of instabilities in reentrant wave patterns, in the presence of ionic gradients in cardiac tissue, is proposed, which may explain how one type of arrhythmia can degenerate into another (VF).
Characterization and Control of Wave Propagation in the Heart
TLDR
This thesis introduces and applies new methods to allow a more detailed characterization of the dynamics during ventricular fibrillation and its interaction with electrical shocks.
Impact of number of co-existing rotors and inter-electrode distance on accuracy of rotor localization.
Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity
TLDR
In a generic 2D setup, it is shown that adipose tissue remodeling substantially affects the spiral wave dynamics resulting in complex arrhythmia and such arrhythmias can be initiated under high frequency pacing if the size of the remodeled tissue is sufficiently large.
Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms.
  • C. Roney, J. Bayer, +7 authors E. Vigmond
  • Medicine
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2016
TLDR
The specific representation of fibrosis has a large effect on rotor dynamics and needs to be carefully considered for patient specific modelling.
Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers
TLDR
Localized optogenetic targeting of rotors in atrial monolayers could lead to both stabilization and destabilization of reentrant activity and may improve the understanding of the mechanisms involved in rotor-guided ablation.
Pro-arrhythmogenic effects of CACNA1C G1911R mutation in human ventricular tachycardia: insights from cardiac multi-scale models
TLDR
The increased repolarization dispersion caused by the G1911R mutation is a primary factor that may primarily contribute to the genesis of cardiac arrhythmias in Timothy Syndrome.
Scroll-wave dynamics in the presence of ionic and conduction inhomogeneities in an anatomically realistic mathematical model for the pig heart
TLDR
This study demonstrates, for the first time, by using a state-of-the-art, anatomically realistic model of the pig heart, how differences in the geometrical and biophysical nature of such inhomogeneities can influence scroll-wave dynamics in different ways.
Global alternans instability and its effect on non-linear wave propagation: dynamical Wenckebach block and self terminating spiral waves
TLDR
Heterogeneity and the area of waveblock can extend itself in space and can result formation of new additional sources, or termination of existing sources of arrhythmias, based on a new form of instability, which is coined as global alternans instability (GAI).
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