Small-scale systems for in vivo drug delivery

  title={Small-scale systems for in vivo drug delivery},
  author={David Lav{\'a}n and Terry McGuire and Robert S. Langer},
  journal={Nature Biotechnology},
Recent developments in the application of micro- and nanosystems for drug administration include a diverse range of new materials and methods. New approaches include the on-demand activation of molecular interactions, novel diffusion-controlled delivery devices, nanostructured 'smart' surfaces and materials, and prospects for coupling drug delivery to sensors and implants. Micro- and nanotechnologies are enabling the design of novel methods such as radio-frequency addressing of individual… 


The recent development of nanoscale and microscale technologies in drug delivery including drug delivery systems, in vitro and in vivo tests are reviewed.

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Using the tools of nanotechnology, drug delivery systems within the nanometer size regime can be developed to alter both pharmacological and therapeutic effects of drug molecules, and offer superior advantages, such as altered pharmacokinetic behaviour and improved payload, over traditional large-scale systems.

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The design of a self-regulated drug delivery device based on the integration of both mechanical and chemical methods is described, where a constant release rate can be achieved by carefully designing the shape of the drug reservoir, while a pH-sensitive hydrogel switch is used to regulate the drug release.

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