Small-scale systems for in vivo drug delivery
@article{Lavn2003SmallscaleSF, title={Small-scale systems for in vivo drug delivery}, author={David Lav{\'a}n and Terry McGuire and Robert S. Langer}, journal={Nature Biotechnology}, year={2003}, volume={21}, pages={1184-1191} }
Recent developments in the application of micro- and nanosystems for drug administration include a diverse range of new materials and methods. New approaches include the on-demand activation of molecular interactions, novel diffusion-controlled delivery devices, nanostructured 'smart' surfaces and materials, and prospects for coupling drug delivery to sensors and implants. Micro- and nanotechnologies are enabling the design of novel methods such as radio-frequency addressing of individual…
1,191 Citations
NANO/MICROSCALE TECHNOLOGIES FOR DRUG DELIVERY
- Biology, Materials Science
- 2011
The recent development of nanoscale and microscale technologies in drug delivery including drug delivery systems, in vitro and in vivo tests are reviewed.
Emerging microtechnologies for the development of oral drug delivery devices.
- BiologyAdvanced drug delivery reviews
- 2012
Advances and challenges of nanotechnology-based drug delivery systems
- Biology, ChemistryExpert opinion on drug delivery
- 2007
Using the tools of nanotechnology, drug delivery systems within the nanometer size regime can be developed to alter both pharmacological and therapeutic effects of drug molecules, and offer superior advantages, such as altered pharmacokinetic behaviour and improved payload, over traditional large-scale systems.
BioMEMS devices for drug delivery
- Biology, EngineeringIEEE Engineering in Medicine and Biology Magazine
- 2009
The ability to generate two-dimensional and three-dimensional material constructs accurately and reproducibly using MEMS may lead to substantial advances over conventional drug delivery systems.
Nanotechnology and Its Drug Delivery Applications
- Biology
- 2016
A broad overview of novel nanoparticle based drug delivery systems is provided, covering its innovations, applications and commercialization systems using both natural and synthetic polymers.
Nanostructure-mediated drug delivery.
- Biology, Materials ScienceNanomedicine : nanotechnology, biology, and medicine
- 2005
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems.
- Biology, EngineeringChemical Society reviews
- 2016
This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.
Novel Platforms for Oral Drug Delivery
- BiologyPharmaceutical Research
- 2008
Oral drug delivery systems of the future are expected to have a significant impact on the treatment of diseases, such as AIDS, cancer, malaria, diabetes requiring complex and multi-drug therapies, as well as on the life of patients, whose age and/or health status make necessary a multiple pharmacological approach.
Potential Devices of Nanostructured
- Biology
- 2017
The biodegradable polymers are playing an important role in the drug delivery by providing controlled release of drugs by crossing the physiological barriers of the patients.
Microchips and controlled-release drug reservoirs.
- Medicine, BiologyWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
- 2010
This review summarizes and updates the development of implantable microchip-containing devices that control dosing from drug reservoirs integrated with the devices. As the expense and risk of new…
References
SHOWING 1-10 OF 154 REFERENCES
Design of a Self-Regulated Drug Delivery Device
- Biology, Materials Science
- 2001
The design of a self-regulated drug delivery device based on the integration of both mechanical and chemical methods is described, where a constant release rate can be achieved by carefully designing the shape of the drug reservoir, while a pH-sensitive hydrogel switch is used to regulate the drug release.
Microfabricated drug delivery systems: from particles to pores.
- Engineering, BiologyAdvanced drug delivery reviews
- 2003
Moving smaller in drug discovery and delivery
- Biology, ChemistryNature Reviews Drug Discovery
- 2002
The emerging micro- and nanotechnology tools, techniques and devices that are being applied to advance the fields of drug discovery and drug delivery are highlighted.
Cationic polymers for gene delivery: designs for overcoming barriers to systemic administration.
- BiologyCurrent opinion in molecular therapeutics
- 2001
Recent efforts in polycation preparations that include the development of new polymers for gene delivery, the modification of traditional polycations with hydrophilic polymer for salt and serum stability and the addition of bioactive functionalities topolymers for enhanced intracellular trafficking result in polymer/DNA composites with increased stability and delivery efficiencies.
A controlled-release microchip
- BiologyNature
- 1999
A solid-state silicon microchip that can provide controlled release of single or multiple chemical substances on demand is reported, based on the electrochemical dissolution of thin anode membranes covering microreservoirs filled with chemicals in solid, liquid or gel form.
Electrically credible polymer gel for controlled release of drugs
- BiologyNature
- 1991
It is shown that the modulated release of insulin, and by extension other macromolecules, can be achieved with this polymeric system, which rapidly changes from a solid state to solution in response to small electric currents, by disintegration of the solid polymer complex into two water-soluble polymers.
Bioadhesive poly(methyl methacrylate) microdevices for controlled drug delivery.
- Biology, ChemistryJournal of controlled release : official journal of the Controlled Release Society
- 2003
Building drug delivery into tissue engineering design
- Biology, EngineeringNature Reviews Drug Discovery
- 2002
The state of the art in controlled-release and microfluidic drug delivery technologies are discussed, and their potential applications for tissue engineering are outlined.
The dawning era of polymer therapeutics
- Biology, ChemistryNature Reviews Drug Discovery
- 2003
The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.