Small-sample inference for incomplete longitudinal data with truncation and censoring in tumor xenograft models.

@article{Tan2002SmallsampleIF,
  title={Small-sample inference for incomplete longitudinal data with truncation and censoring in tumor xenograft models.},
  author={Ming Tan and Hong-Bin Fang and Guo-Liang Tian and Peter J. Houghton},
  journal={Biometrics},
  year={2002},
  volume={58 3},
  pages={
          612-20
        }
}
  • Ming Tan, Hong-Bin Fang, +1 author Peter J. Houghton
  • Published in Biometrics 2002
  • Mathematics, Medicine
  • In cancer drug development, demonstrating activity in xenograft models, where mice are grafted with human cancer cells, is an important step in bringing a promising compound to humans. A key outcome variable is the tumor volume measured in a given period of time for groups of mice given different doses of a single or combination anticancer regimen. However, a mouse may die before the end of a study or may be sacrificed when its tumor volume quadruples, and its tumor may be suppressed for some… CONTINUE READING

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