Small prostate size and high grade disease--biology or artifact?

@article{Liu2011SmallPS,
  title={Small prostate size and high grade disease--biology or artifact?},
  author={Jen-Jane Liu and James D. Brooks and M-C. Ferrari and Rosie Nolley and Joseph Charles Presti},
  journal={The Journal of urology},
  year={2011},
  volume={185 6},
  pages={
          2108-11
        }
}
PURPOSE Prior radical prostatectomy series have shown an inverse association between prostate size and high grade cancer. It has been suggested that smaller size prostates arise in a low androgen environment, enabling development of more aggressive cancer. We propose that this observation is the result of ascertainment bias driven by prostate specific antigen performance. MATERIALS AND METHODS We identified 1,404 patients from the Stanford Radical Prostatectomy Database with clinical stage… CONTINUE READING
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