Small potassium ion channel proteins encoded by chlorella viruses.

  title={Small potassium ion channel proteins encoded by chlorella viruses.},
  author={Ming Kang and Anna Moroni and Sabrina Gazzarrini and Dario DiFrancesco and Gerhard Thiel and Maria Severino and James L Van Etten},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 15},
Kcv, a 94-aa protein encoded by Paramecium bursaria chlorella virus 1, is the smallest known protein to form a functional potassium ion channel and basically corresponds to the "pore module" of potassium channels. Both viral replication and channel activity are inhibited by the ion channel blockers barium and amantadine but not by cesium. Genes encoding Kcv-like proteins were isolated from 40 additional chlorella viruses. Differences in 16 of the 94 amino acids were detected, producing six Kcv… CONTINUE READING