Small nucleolar RNA-derived microRNA hsa-miR-1291 modulates cellular drug disposition through direct targeting of ABC transporter ABCC1.

@article{Pan2013SmallNR,
  title={Small nucleolar RNA-derived microRNA hsa-miR-1291 modulates cellular drug disposition through direct targeting of ABC transporter ABCC1.},
  author={Yu-Zhuo Pan and Amy Zhou and Zihua Hu and Aiming Yu},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2013},
  volume={41 10},
  pages={1744-51}
}
Multidrug resistance-associated protein 1 (MRP1/ABCC1) is an important membrane transporter that contributes to cellular disposition of many endobiotic and xenobiotic agents, and it can also confer multidrug resistance. This study aimed to investigate the role of human noncoding microRNA-1291 (hsa-miR-1291) in regulation of ABCC1 and drug disposition. Bioinformatics analyses indicated that hsa-miR-1291, localized within the small nucleolar RNA H/ACA box 34 (SNORA34), might target ABCC1 3… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

MiRNAs and miRNA Polymorphisms Modify Drug Response

International journal of environmental research and public health • 2016
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2006
View 4 Excerpts
Highly Influenced

microRNAs as mediators of drug toxicity.

Annual review of pharmacology and toxicology • 2013
View 3 Excerpts

Noncoding microRNAs: Small RNAs play a big role in regulation of ADME

AM Yu, YZ Pan
Acta Pharmaceutica Sinica B • 2012
View 3 Excerpts

Similar Papers

Loading similar papers…