Small nucleolar RNA 47 promotes tumorigenesis by regulating EMT markers in hepatocellular carcinoma.

@article{Li2017SmallNR,
  title={Small nucleolar RNA 47 promotes tumorigenesis by regulating EMT markers in hepatocellular carcinoma.},
  author={Guangcai Li and Yuan He and Xiaoqing Liu and Zhen Zheng and Ming Zhang and Faxiang Qin and Xiong Lan},
  journal={Minerva medica},
  year={2017},
  volume={108 5},
  pages={396-404}
}
BACKGROUND Hepatocellular carcinoma (HCC) is third leading cause of cancer-related death globally. Evidence suggest that small nucleolar RNAs (snoRNAs) have emerged as key regulators of tumor development and progression in HCC. However, the biological significance of snoRNAs in HCC remains unclear. METHODS We investigated the role of snoRA47 in a total of 60 paired HCC samples and six different human HCC cell lines by using qRT-PCR. Besides, snoRA47 was silenced through the siRNA transfection… CONTINUE READING