Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.

@article{Makarov2002SmallNR,
  title={Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.},
  author={Evgeny M. Makarov and Olga V. Makarova and Henning Urlaub and Marc Gentzel and Cindy L Will and Matthias Wilm and Reinhard L{\"u}hrmann},
  journal={Science},
  year={2002},
  volume={298 5601},
  pages={
          2205-8
        }
}
Major structural changes occur in the spliceosome during its activation just before catalyzing the splicing of pre-messenger RNAs (pre-mRNAs). Whereas changes in small nuclear RNA (snRNA) conformation are well documented, little is known about remodeling of small nuclear ribonucleoprotein (snRNP) structures during spliceosome activation. Here, human 45S activated spliceosomes and a previously unknown 35S U5 snRNP were isolated by immunoaffinity selection and were characterized by mass… CONTINUE READING

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