Small molecules that regulate lifespan: evidence for xenohormesis.

@article{Lamming2004SmallMT,
  title={Small molecules that regulate lifespan: evidence for xenohormesis.},
  author={Dudley W Lamming and Jason G Wood and David A. Sinclair},
  journal={Molecular microbiology},
  year={2004},
  volume={53 4},
  pages={
          1003-9
        }
}
Barring genetic manipulation, the diet known as calorie restriction (CR) is currently the only way to slow down ageing in mammals. The fact that CR works on most species, even microorganisms, implies a conserved underlying mechanism. Recent findings in the yeast Saccharomyces cerevisiae indicate that CR extends lifespan because it is a mild biological stressor that activates Sir2, a key component of yeast longevity and the founding member of the sirtuin family of deacetylases. The sirtuin… CONTINUE READING

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