Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action.

@article{TargettAdams2011SmallMT,
  title={Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action.},
  author={Paul Targett-Adams and Emily J S Graham and Jenny Middleton and Amy N. S. Palmer and Stephen M. Shaw and Helen Lavender and Philip Brain and Thien Duc Tran and Lyn H Jones and Florian M Wakenhut and Blanda L C Stammen and D C Pryde and Chris Pickford and M. W. Westby},
  journal={Journal of virology},
  year={2011},
  volume={85 13},
  pages={
          6353-68
        }
}
The current standard of care for hepatitis C virus (HCV)-infected patients consists of lengthy treatment with interferon and ribavirin. To increase the effectiveness of HCV therapy, future regimens will incorporate multiple direct-acting antiviral (DAA) drugs. Recently, the HCV-encoded NS5A protein has emerged as a promising DAA target. Compounds targeting NS5A exhibit remarkable potency in vitro and demonstrate early clinical promise, suggesting that NS5A inhibitors could feature in future DAA… CONTINUE READING
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Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins

  • Shi, T S.
  • Virology
  • 2002
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