Small molecules for reprogramming and transdifferentiation

  title={Small molecules for reprogramming and transdifferentiation},
  author={Hua Qin and Andong Zhao and Xiaobing Fu},
  journal={Cellular and Molecular Life Sciences},
Pluripotency reprogramming and transdifferentiation induced by transcription factors can generate induced pluripotent stem cells, adult stem cells or specialized cells. However, the induction efficiency and the reintroduction of exogenous genes limit their translation into clinical applications. Small molecules that target signaling pathways, epigenetic modifications, or metabolic processes can regulate cell development, cell fate, and function. In the recent decade, small molecules have been… 

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