Small molecules enable highly efficient neuronal conversion of human fibroblasts

  title={Small molecules enable highly efficient neuronal conversion of human fibroblasts},
  author={Julia Ladewig and J{\'e}r{\^o}me Mertens and Jaideep C. Kesavan and Jonas Doerr and Daniel Poppe and Finnja Glaue and Stefan Herms and Peter Wernet and Gesine Koegler and Franz-Josef Mueller and Philipp Koch and Oliver Bruestle},
  journal={Nature Methods},
Forced expression of proneural transcription factors has been shown to direct neuronal conversion of fibroblasts. Because neurons are postmitotic, conversion efficiencies are an important parameter for this process. We present a minimalist approach combining two-factor neuronal programming with small molecule–based inhibition of glycogen synthase kinase-3β and SMAD signaling, which converts postnatal human fibroblasts into functional neuron-like cells with yields up to >200% and neuronal… CONTINUE READING
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