Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.

@article{Borowiak2009SmallME,
  title={Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.},
  author={Malgorzata Borowiak and Ren{\'e} Maehr and Shuibing Chen and Alice E Chen and Weiping Tang and Julia L. Fox and Stuart L. Schreiber and Douglas A. Melton},
  journal={Cell stem cell},
  year={2009},
  volume={4 4},
  pages={348-58}
}
An essential step for therapeutic and research applications of stem cells is the ability to differentiate them into specific cell types. Endodermal cell derivatives, including lung, liver, and pancreas, are of interest for regenerative medicine, but efforts to produce these cells have been met with only modest success. In a screen of 4000 compounds, two cell-permeable small molecules were indentified that direct differentiation of ESCs into the endodermal lineage. These compounds induce nearly… CONTINUE READING
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