Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface

@article{McKinsey2007SmallmoleculeTF,
  title={Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface},
  author={Timothy A McKinsey and David A. Kass},
  journal={Nature Reviews Drug Discovery},
  year={2007},
  volume={6},
  pages={617-635}
}
Pathological stress from cardiovascular disease stimulates hypertrophy of heart cells, which increases the risk of cardiac morbidity and mortality. Recent evidence has indicated that inhibiting such hypertrophy could be beneficial, encouraging drug discovery and development efforts for agents that could achieve this goal. Most existing therapies that have antihypertrophic effects target outside–in signalling in cardiac cells, but their effectiveness seems limited, and so attention has recently… CONTINUE READING
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