Small-molecule pheromones that control dauer development in Caenorhabditis elegans.

  title={Small-molecule pheromones that control dauer development in Caenorhabditis elegans.},
  author={Rebecca A Butcher and Masaki J. Fujita and Frank C Schroeder and Jon Clardy},
  journal={Nature chemical biology},
  volume={3 7},
In response to high population density or low food supply, the nematode Caenorhabditis elegans enters an alternative larval stage, known as the dauer, that can withstand adverse conditions for prolonged periods. C. elegans senses its population density through a small-molecule signal, traditionally called the dauer pheromone, that it secretes into its surroundings. Here we show that the dauer pheromone consists of several structurally related ascarosides-derivatives of the dideoxysugar… CONTINUE READING

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