Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts.

@article{Wang2006SmallmoleculeMO,
  title={Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts.},
  author={Wenge Wang and Seok-Hyun Kim and Wafik S El-Deiry},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 29},
  pages={11003-8}
}
p53 deficiency is common in almost all human tumors and contributes to an aggressive chemo- or radiotherapy-resistant phenotype, therefore providing a target for drug development. Molecular targeting to restore wild-type p53 activity has been attempted in drug development and has led to the identification of CP-31398, PRIMA1, and the Nutlins. However, strategies targeting p53-activated transcriptional responses or p53 family member expression in p53-deficient tumors have yet to be explored… CONTINUE READING