Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

@article{Longo2013SmallmoleculeMO,
  title={Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease},
  author={Frank M Longo and Stephen M Massa},
  journal={Nature Reviews Drug Discovery},
  year={2013},
  volume={12},
  pages={507-525}
}
Neurotrophins and their receptors modulate multiple signalling pathways to regulate neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity. Neurotrophins have potential for the treatment of neurological diseases. However, their therapeutic application has been limited owing to their poor plasma stability, restricted nervous system penetration and, importantly, the pleiotropic actions that derive from their concomitant binding to multiple receptors. One strategy… 
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