Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma.

@article{Young2010SmallMM,
  title={Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma.},
  author={D. Young and Colleen M. Connelly and Christoph Grohmann and A. Deiters},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 23},
  pages={
          7976-81
        }
}
MicroRNAs are a recently discovered new class of important endogenous regulators of gene function. Aberrant regulation of microRNAs has been linked to various human diseases, most importantly cancer. Small molecule intervention of microRNA misregulation has the potential to provide new therapeutic approaches to such diseases. Here, we report the first small molecule inhibitors and activators of the liver-specific microRNA miR-122. This microRNA is the most abundant microRNA in the liver and is… Expand
MicroRNA miR-122 as a therapeutic target for oligonucleotides and small molecules.
High-Throughput Luciferase Reporter Assay for Small-Molecule Inhibitors of MicroRNA Function
MicroRNA-targeting therapeutics for hepatitis C
Identification of inhibitors of microRNA function from small molecule screens.
Aryl amide small-molecule inhibitors of microRNA miR-21 function.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 23 REFERENCES
Positive and negative modulation of viral and cellular mRNAs by liver-specific microRNA miR-122.
LNA-mediated microRNA silencing in non-human primates
miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines.
...
1
2
3
...