Small-molecule mimics of an α-helix for efficient transport of proteins into cells

@article{Okuyama2007SmallmoleculeMO,
  title={Small-molecule mimics of an $\alpha$-helix for efficient transport of proteins into cells},
  author={Masahiro Okuyama and Heike Laman and Sarah R. Kingsbury and Cristina Visintin and Elisabetta Leo and Kathryn Leigh Eward and Kai Stoeber and Christopher Boshoff and Gareth Haydn Williams and David L. Selwood},
  journal={Nature Methods},
  year={2007},
  volume={4},
  pages={153-159}
}
We designed and synthesized small-molecule mimics of an alpha-helical peptide protein transduction domain (PTD). These small-molecule carriers, which we termed SMoCs, are easily coupled to biomolecules, and efficiently deliver dye molecules and recombinant proteins into a variety of cell types. We designed the SMoCs using molecular modeling techniques. As an example of a protein cargo, we applied this new technology to the internalization of the DNA replication licensing repressor geminin, in… 

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