Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis.

Abstract

Fibrosis, a disease in which excessive amounts of connective tissue accumulate in response to physical damage and/or inflammatory insult, affects nearly every tissue in the body and can progress to a state of organ malfunction and death. A hallmark of fibrotic disease is the excessive accumulation of extracellular matrix-secreting activated myofibroblasts… (More)
DOI: 10.1073/pnas.1702750114

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