Small molecule ligands define a binding site on the immune regulatory protein B7.1.

@article{Erbe2002SmallML,
  title={Small molecule ligands define a binding site on the immune regulatory protein B7.1.},
  author={David V. Erbe and Suyue Wang and Yuzhe Xing and James Finbarr Tobin},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 9},
  pages={
          7363-8
        }
}
The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases. To this end, specific small molecule inhibitors of human B7.1 were identified and characterized. These compounds inhibit the binding of B7.1 to both CD28 and CTLA4. Both classes of compounds… CONTINUE READING
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