Small molecule intercalation with double stranded DNA: implications for normal gene regulation and for predicting the biological efficacy and genotoxicity of drugs and other chemicals.

@article{Hendry2007SmallMI,
  title={Small molecule intercalation with double stranded DNA: implications for normal gene regulation and for predicting the biological efficacy and genotoxicity of drugs and other chemicals.},
  author={Lawrence B. Hendry and Virendra B. Mahesh and Edwin D. Bransome and Douglas E. Ewing},
  journal={Mutation research},
  year={2007},
  volume={623 1-2},
  pages={53-71}
}
The binding of small molecules to double stranded DNA including intercalation between base pairs has been a topic of research for over 40 years. For the most part, however, intercalation has been of marginal interest given the prevailing notion that binding of small molecules to protein receptors is largely responsible for governing biological function. This picture is now changing with the discovery of nuclear enzymes, e.g. topoisomerases that modulate intercalation of various compounds… CONTINUE READING
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