Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm.

@article{Willems2011SmallmoleculeIO,
  title={Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm.},
  author={Erik Willems and Sean Spiering and Herman Davidovics and Marion C Lanier and Zebin Xia and Marcia H Dawson and John R Cashman and Mark Mercola},
  journal={Circulation research},
  year={2011},
  volume={109 4},
  pages={
          360-4
        }
}
RATIONALE Human embryonic stem cells can form cardiomyocytes when cultured under differentiation conditions. Although the initiating step of mesoderm formation is well characterized, the subsequent steps that promote for cardiac lineages are poorly understood and limit the yield of cardiomyocytes. OBJECTIVE Our aim was to develop a human embryonic stem cell-based high-content screening assay to discover small molecules that drive cardiogenic differentiation after mesoderm is established to… CONTINUE READING

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