Small-molecule inhibitors of the PI3K signaling network.

  title={Small-molecule inhibitors of the PI3K signaling network.},
  author={Colleen R. McNamara and Alexei Degterev},
  journal={Future medicinal chemistry},
  volume={3 5},
The phosphoinositide 3-kinase (PI3K) signaling pathway controls a wide variety of cellular processes including cell death and survival, cell migration, protein synthesis and metabolism. Aberrant PI3K-dependent signaling, mediated by Akt kinase, has been implicated in many human diseases including cancer, inflammation, cardiovascular disease and metabolic diseases, making this pathway a principle target for drug development. In this article we will summarize the PI3K signaling network and… CONTINUE READING
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