Small molecule inhibitors of the HPV16-E6 interaction with caspase 8.

Abstract

High-risk strains of human papillomaviruses (HPVs) cause nearly all cases of cervical cancer as well as a growing number of head and neck cancers. The oncogenicity of these viruses can be attributed to the activities of their two primary oncoproteins, E6 and E7. The E6 protein has among its functions the ability to prevent apoptosis of infected cells… (More)
DOI: 10.1016/j.bmcl.2011.12.145

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Cite this paper

@article{Yuan2012SmallMI, title={Small molecule inhibitors of the HPV16-E6 interaction with caspase 8.}, author={Chung-Hsiang Yuan and Maria Filippova and Sandy S. Tungteakkhun and Penelope Jayne Duerksen-Hughes and John L. Krstenansky}, journal={Bioorganic & medicinal chemistry letters}, year={2012}, volume={22 5}, pages={2125-9} }