Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse.

@article{Swingle2007SmallmoleculeIO,
  title={Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse.},
  author={Mark R. Swingle and Li Ni and Richard Eric Honkanen},
  journal={Methods in molecular biology},
  year={2007},
  volume={365},
  pages={23-38}
}
Natural product extracts have proven to be a rich source of small molecules that potently inhibit the catalytic activity of certain PPP-family ser/thr protein phosphatases. To date, the list of inhibitors includes okadaic acid (produced by marine dinoflagelates, Prorocentrum sp. and Dinophysis sp.), calyculin A, dragmacidins (isolated from marine sponges), microcystins, nodularins (cyanobacteria, Microcystis sp. and Nodularia sp.), tautomycin, tautomycetin, cytostatins, phospholine… CONTINUE READING
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