Small-molecule inhibitors of protein–protein interactions: progressing towards the dream

  title={Small-molecule inhibitors of protein–protein interactions: progressing towards the dream},
  author={Michelle R. Arkin and James A. Wells},
  journal={Nature Reviews Drug Discovery},
  • M. ArkinJ. Wells
  • Published 1 April 2004
  • Biology, Chemistry
  • Nature Reviews Drug Discovery
Protein–protein interactions have a key role in most biological processes, and offer attractive opportunities for therapeutic intervention. Developing small molecules that modulate protein–protein interactions is difficult, owing to issues such as the lack of well-defined binding pockets. Nevertheless, there has been important progress in this endeavour in recent years. Here, we use illustrative examples to discuss general strategies for addressing the challenges inherent in the discovery and… 

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