Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth.

@article{Baryawno2010SmallmoleculeIO,
  title={Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth.},
  author={Ninib Baryawno and Baldur Sveinbj{\"o}rnsson and Staffan Eksborg and C Chen and Per Kogner and John Inge Johnsen},
  journal={Cancer research},
  year={2010},
  volume={70 1},
  pages={266-76}
}
Activation of the beta-catenin and receptor kinase pathways occurs often in medulloblastoma, the most common pediatric malignant brain tumor. In this study, we show that molecular cross-talk between the beta-catenin and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways is crucial to sustain medulloblastoma pathophysiology. Constitutive activation of phosphoinositide-dependent protein kinase 1 (PDK1), Akt, and phosphorylation of [corrected] glycogen synthase kinase 3beta (GSK-3beta… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/ Cancer Res

  • B Geoerger, K Kerr, CB Tang
  • Cancer Res
  • 2010
1 Excerpt

Essential role of PDK1 in Cancer Res

  • MA Lawlor, A Mora, PR Ashby
  • Baryawno et al
  • 2010
1 Excerpt

Small - molecule inhibitors of phosphatidylinositol 3 - kinase / Akt signaling inhibit Wnt / β - catenin pathway cross - talk and suppress medulloblastoma growth

  • N Baryawno, B Sveinbjörnsson, S Eksborg, Chen C-S, P Kogner, JI Johnsen
  • Cancer Res
  • 2010

Similar Papers

Loading similar papers…