Small-molecule inhibitors of myosin proteins.

  title={Small-molecule inhibitors of myosin proteins.},
  author={Lisa M. Bond and David A Tumbarello and John Kendrick-Jones and Folma Buss},
  journal={Future medicinal chemistry},
  volume={5 1},
Advances in screening and computational methods have enhanced recent efforts to discover/design small-molecule protein inhibitors. One attractive target for inhibition is the myosin family of motor proteins. Myosins function in a wide variety of cellular processes, from intracellular trafficking to cell motility, and are implicated in several human diseases (e.g., cancer, hypertrophic cardiomyopathy, deafness and many neurological disorders). Potent and selective myosin inhibitors are… CONTINUE READING

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