Small-molecule inhibitors of NF-kappaB for the treatment of inflammatory joint disease.

@article{Roshak2002SmallmoleculeIO,
  title={Small-molecule inhibitors of NF-kappaB for the treatment of inflammatory joint disease.},
  author={Amy K. Roshak and James F. Callahan and Simon M Blake},
  journal={Current opinion in pharmacology},
  year={2002},
  volume={2 3},
  pages={316-21}
}
Recent advances in our understanding of the role of cytokine networks in inflammatory processes have led to the development of novel biological agents for the treatment of chronic inflammatory diseases. At the present time, significant efforts are focused on characterizing the complex signal transduction cascades that are activated by these cytokines and, in turn, regulate their expression. The transcription factor NF-kappaB is a pivotal regulator of the inducible expression of key… CONTINUE READING

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