Small molecule inhibitors of HIVgp41 N-heptad repeat trimer formation.

Abstract

Identification of mechanistically novel anti-HIV fusion inhibitors was accomplished using a computer-aided structure-based design approach with the goal of blocking the formation of the N-heptad repeat (NHR) trimer of the viral protein gp41. A virtual screening strategy that included per-residue interaction patterns (footprints) was employed to identify… (More)
DOI: 10.1016/j.bmcl.2015.04.067

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