Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods.

Abstract

The pharmacological suppression of the DNA damage response and DNA repair can increase the therapeutic indices of conventional chemotherapeutics. Replication Protein A (RPA), the major single-stranded DNA binding protein in eukaryotes, is required for DNA replication, DNA repair, DNA recombination, and DNA damage response signaling. Through the use of high… (More)
DOI: 10.1016/j.bmc.2011.03.012

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