Small-molecule control of protein degradation using split adaptors.

Abstract

Targeted intracellular degradation provides a method to study the biological function of proteins and has numerous applications in biotechnology. One promising approach uses adaptor proteins to target substrates with genetically encoded degradation tags for proteolysis. Here, we describe an engineered split-adaptor system, in which adaptor assembly and… (More)
DOI: 10.1021/cb2001389

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